Prof. Serge GOLDMAN, Ph. D., ULB, Erasme Hospital
Serge Goldman was born in 1957 and he studied at the Medical School of the Université Libre de Bruxelles. He is MD with successive certifications in neurology and in nuclear medicine and with a thesis leading to the “agrégation de l’enseignement supérieur” in Medical Science. He is head of the Department of Nuclear Medicine and the PET/Biomedical Cyclotron Unit at ULB - Erasme Hospital since 2002. He got trained in PET imaging during a fellowship at Johns Hopkins University in the research group of Pr. H.N. Wagner. He has published 185 full articles and a dozen of book chapters during the last 25 years. Most of his scientific production relates to PET imaging, including for animal models. His main field of research is imaging of brain tumors with a particular stress put on the integration of molecular imaging in therapy targeting. Other fields of interest are imaging for cell tracking and neurological applications of PET, in particular in the domains of neurodegeneration, epilepsy and development. He has been President of the Belgian Society of Nuclear Medicine from 2007 to 2010.
Gilles DOUMONT, Ph. D.
Gilles Doumont got his Master in Chemistry in 1999 at the Université Libre de Bruxelles (ULB). He then started a PhD in Molecular Biology in the IBMM-ULB, and graduated in 2005. Oncology constituted his area of interest. In particular he focused on the study of two new mediators of the biological activity of the tumour suppressor p53. To extend his area of competencies in Oncology he started to work as postdoctoral researcher in NKI-AVL, Amsterdam, The Netherlands, an institute entirely dedicated to cancer research. The aim of his research was to identify new critical molecules involved in metastasis development using a mouse model for invasive lobular carcinoma, one of the most invasive breast cancers affecting women. He had the financial support of the European Molecular Biology Organization (EMBO long term fellowship). Back in Belgium in April 2011 Gilles Doumont is working as a researcher at the CMMI.
Nuclear molecular imaging - ex vivo
- Micro-Imager (Biospace Lab, France)
- F. Biver, F. Lotstra, M. Monclus, S. Dethy, P. Damhaut, D. Wikler, A. Luxen, and S. Goldman, In vivo binding of [18F] altanserin to rat brain 5HT2 receptors: a fi lm and electronic autoradiographic study, Nucl Med Biol 24, pp 357-60 (1997)
- S.N. Schiffmann, S. Goldman, P. Heyman, M. De Vuyst, G. De Roy, and J.J. Vanderhaeghen, Ontogeny of cholecystokinin receptors in the human striatum, Neurosci Lett 141, pp 39-42 (1992)
- S. Goldman, D. Pelaprat, O. Van Reeth, B. Roques, and J.J. Vanderhaeghen, Autoradiographic localization of cholecystokinin binding sites in human cerebellar system using a [125I]CCK8 probe, Neurochem Int 10, pp 467-471 (1987)
Description and applications
The nuMIx lab is specialized in preclinical nuclear imaging in vivo and ex vivo. nuMix is proposing services in quantitative digital autoradiography using a last generation MicroImager detector (Biospace Lab, France).
Autoradiography is a high-resolution (μm range) and high-sensitivity 2D molecular imaging technique depicting radiation distribution in histological (ex vivo) slices. In Autoradiography particles originating from the radiotracer incorporated in the slices are routinely recorded on a radiosensitive film or emulsion placed in direct contact with the specimen.
A new generation system, the MicroImager™ acquired by the CMMI delivers autoradiography data in a digital form due to the scintillating emulsion being coupled to a cooled and intensifing CCD camera. The MicroImager™ allows real-time image formation and quantitation without under- or overexposure, with an outstanding sensitivity by many orders of magnitude better than standard techniques. Additionally, the MicroImager™ enables direct quantitation of patterns of radiotracer distribution (real counting of detected particles from slices), as well as simultaneous imaging and discrimination of different radionuclides in specimens with multiple radiolabelling.
See the poster: POSTER_CMMI_-_nuMix.pdf